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Well tanks and mobile artillery in a city full of sky scrapers is a dumb idea. So I'd most likely go for an air assualt. Common sense says you use weapons with a long stand off range. There are some pretty big missiles and bombs out there that I'm sure would do a number on any living organism.
That or if there's a large subway system, you could always fill it with some sort of explosive and create the world's largest IED.
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