A .38 or .357 loaded with a nasty-ass hollowpoint like a Golden Saber or something similar will solve -most- self-defense related problems. An automatic gives you more capacity, and a longarm gives you greater range and MUCH greater power, but a 6-shooter will still get you through most touchy spots.
Put it this way, if 6 rounds of .357 pushing 124-grain JHPs of some suitable flavour won't solve your problem, you've got SERIOUS problems and it's probably time to reach for a 12-bore or .308.
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