Malcom in the Middle. I'm suprised that no one mentioned this one. Disfunctional family hyjinks for the whole family.
South Park. It's been on for over ten years and still going strong.
Drawn Together. Now this series is funny and distrubing on so many levels. It's an animated show that does pretends it's a reality tv show with paradies of popular cartoon characters, such as a disney princess, a superhero, a video game character, and a musical mystery solving gal (like from the Scooby gang). In fact, it's so disturbing, crass, crude, and discusting, that prehaps you shouldn't watch it. But it's got some great laughs once you get pass all this