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More often than not, you won't be able to. Even Adobe's editor (Acrobat) is not capable of modifying text or layout.
Your only real hope for modifying a PDF is to have access to the source. If it professionally generated, it was probably done in Indesign. If you can get your hands on the .indd file, you'll be golden.
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"I'm typing on a computer of science, which is being sent by science wires to a little science server where you can access it. I'm not typing on a computer of philosophy or religion or whatever other thing you think can be used to understand the universe because they're a poor substitute in the role of understanding the universe which exists independent from ourselves." - Willravel
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