I'm thirding or fourthing or whatever the suggestions that defending oneself with a knife is a dumb idea. As said (or implied) before, if someone is close enough for a knife, then they are close enough for hand-to-hand combat, which is likely to be equally as effective in your defense. The difference is that, with hand-to-hand, you may disable simply via knockout, holds, or perhaps breaking a couple of important limbs. With a knife, you're probably going to have to kill the poor bastard in order to effectively defend yourself against the assailant. It's messy, morally questionable (given the other, equally good options), and unneccessary.
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"Few people are capable of expressing with equanimity opinions which differ from the prejudices of their social environment. Most people are even incapable of forming such opinions." - Albert Einstein
"Wise men talk because they have something to say; fools, because they have to say something." - Plato
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