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Yeah RetinA and other antibiotics are the big guns. They only help with the whiteheads, not with blackheads, since they don't control sebum, only bacteria. RetinA has its own host of side effects and most doctors I know only prescribe it if the acne is bad enough to cause scarring. Topical antibiotics are milder but man oh man do they smell bad :P I don't know anything about Proactiv though.
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