Games that require it (Zelda, Brain Age) have a configuration option right at the beginning which asks whether you are right or left handed. Brain Age is vertical (DS is sideways), so switching hands there is really important. You should be fine.
And yea, FF2 was the first game I ever played, so I'm similarly in love with Final Fantasy.
EDIT: Just saw this:
Quote:
So I guess my decision is the DS. The only qualm I have is that I would be so mad if they released a new handheld in short manner after I buy this DS.
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Careful, then..
http://www.pcworld.com/article/id,13...1/article.html
They're talking about re-re-releasing the DS, in its third iteration. It's something to think about, especially if you'd be terribly upset by it. It's supposedly still in the works, but Nintendo has confirmed it.