I'd have to agree with Munku. You can't compare a .22 and a .45 on the same plain when it comes to self-defense. Shot placement is going to be tough when you're faced with the adreniline and fear associated with someone threatening your life. You wake up in the night to some dude in your bedroom touting a knife and threatening to kill you you're not going to ask him to hold still while you turn the lights on and aim for his eye.
Just my two cents. You want point and shoot and not have to repeat.
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