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It depends on the sandwich. Weight loss, when it comes down to it, is burning more calories in a day then you take in. I guarantee that I could replace two meals a day with subway and gain weight, or I could replace subway with two meals a day and lose weight. If I order, in each meal, a footlong meatball sub, or a footlong chicken bacon ranch, each slathered with cheese and a high fat/calorie dressing, cookies and a large coke... well, that's probably about 2000 calories a meal. A 6 inch chicken/turkey/ham on wheat, no cheese, with baked chips (or no chips) and diet coke is much different.
The subway marketers are obviously not dumb people. They know that a majority of people are going to go into subway, order a 1500 calorie sub, AND leave feeling good about themselves because "they ate at subway for lunch". In the end, it's all a matter of what you order. Martian is absolutely right in that there is no reason to believe that HFCS and the skyrocketing obesity problem are related.
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Go Pistons!
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