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Seriously, almost everyone has e. coli living in their intestines. As long as it's confined there, the body can handle it. The problems start when it's introduced somewhere else, like the upper digestive system. If the e. coli somehow managed to migrate upwards in the gut, it would cause problems. Before the advent of the powerful antibiotics we have now, a deep puncture wound to the abdomen was usually fatal because all the flora and fauna escaped their usual areas and started attacking tissues that couldn't handle their presence.
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