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I saved them all, but only because, in the end, you get more adam than by harvesting them* and you get the "good" ending.
Of course, I haven't put together any numbers myself, but what I've read on the "teh Internets" is in general accordance with my experience. Saving all the little buggers I had no trouble maxing out all my tracks and buying a wide variety of plasmids and such my first run through.
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No signature. None. Seriously.
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