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I've never heard anything good about Depo from any of my friends who have been on it. Weight gain, irregular bleeding, other hormonal issues.
Unfortunately, birth control side effects are almost impossible to predict on an individual level. Two women on the same pill may have almost entirely opposite reactions.
I understand your frustration - I've packed on 10-15 lbs in a year since getting the IUD, but in my mind it's better than permanently gaining the permanently added weight of a child at this point. You may just have to try some different formulations of pills for a while to see what works best for you. Have you been on triphasic or monophasic pills? (Are they the same dosage throughout the cycle, or does the dosage and hormone composition change every week? In other words, are the pills all the same color or different colors every week?) Have you tried taking the continuous dose ones that let you skip your period altogether?
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"If ten million people believe a foolish thing, it is still a foolish thing."
- Anatole France
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