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Originally Posted by tenniels
I don't know about things like SSRI's and Accutane causing suicide or homicidal/suicidal rampages. I've been on both types of drugs, and never had any of those feelings. I think in order for that to happen there would have to be an underlying urge in the first place.
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The idea of suicidal thoughts actually being enhanced or increased in frequency/severity is more a phenomenon of children and adolescents, not so much in adults. This is generally attributed to/explained as the differences in the way that the neurochemical makeup in our brains function as kids vs. adults. As kids/adolescents, things are very much in flux and it's believed that the increase of suicidal thoughts in that age group is due to the way their constantly-changing serotonin levels react to the drugs. Some circles believe it boils down to making them "more confused" instead of "more focused". In adults, our neurochemical balance doesn't (normally) change/fluctuate nearly as much as it does in adolescents, so the drug has a more controlled environment in which to operate. This generally means a more steady thought-pattern for the user.
Oh, and I haven't read of an FDA clinical drug trial
yet where a kid actually DID kill themselves. It's not just Pfizer, they have all been super-cautious (or maybe super lucky) about it.