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My first thought is that once you replace the brain, you're not human. Or, at the very least, you're not you. If you think about Alzheimer's patients, as their brain deteriorates, they lose themselves, literally. They don't just forget who you are, they forget who they are as well. The brain contains the pieces of the puzzle that make up you. If you replace that with an artificial reproduction, it's not really you, it's just a copy of the genuine article.
The brain is what makes you human. Lose your mind, lose your humanity.
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Cameron originally envisioned the Terminator as a small, unremarkable man, giving it the ability to blend in more easily. As a result, his first choice for the part was Lance Henriksen. O. J. Simpson was on the shortlist but Cameron did not think that such a nice guy could be a ruthless killer.
-From the Collector's Edition DVD of The Terminator
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