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its not so much safety as potency for most drugs, especially OTC (over the counter). They just lose their effectiveness after time, kind of like how a pot of chili tastes great for the first week, then just begins to go stale. It also means that you could theoretically take MORE than the prescribed amount because it is less effective, but that is most often, and rightly discouraged because it is unknown by how much the effectiveness has degraded.
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