You know, I think Issac can fight the future, he's just in denial about it. I mean, he could have simply, not been home, the night that Sylar would come by to kill him 
And there was a golden oppertunity to put a bullet in Sylar's brain this episode, and they didn't take it. ARG!
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"I don't know that I ever wanted greatness, on its own. It seems rather like wanting to be an engineer, rather than wanting to design something - or wanting to be a writer, rather than wanting to write. It should be a by-product, not a thing in itself. Otherwise, it's just an ego trip."
Roger Zelazny
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