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A .410 will kill anything that walks the Lower 48...if you're close enough. It's a great platform for squirrels, rabbits, quail, dove, maybe even grouse if you're fast enough. Anything bigger than that, and you need to be miiighty close for that little shot-string to still be cohesive enough to put enough pellets into the target to kill. .410 slugs are fine loads for deer in thick brush, but slugs and shot are two differnt considerations.
If you're wanting to chase waterfowl, go for the 20-bore. I personally find 20s much less pleasant to shoot than 12s; they seem to have a sharper, more forceful recoil. But for big birds at long ranges, you need that extra charge of shot. All birdshot of the same size is going to run out of steam at about the same distance, regardless of bore size, if te vlocities are roughly equal. At that point, the question becomes one of hit count, which is a function of the size of the string and number of pellets in the air.
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