I think that the most efficient way is to contact a patent attorney. That's what they do. They'll also file the patent if it's possible. Most decent sized reputable law firms have at least one patent attorney on staff or that they can recommend. They're usually specialists, like litigators or bankruptcy attorneys, so you don't want any Tom, Dick or Harry. If you know an attorney and trust him, I'd ask for a recommendation.
I suppose you could also do the search yourself, but I really don't know you go about doing that.
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