Wow, Mal...for someone who doesn't drive, you know a lot about this area
Pan, not sure how far south into Ohio you are, but, I think PJ might be onto something...you aren't that far from Toronto, Niagara Falls, etc. (less than 600 miles). You could swing up through Canada, visit Toronto, then come down through upstate NY ( a scenic area and lots of towns), down into MA and the east coast before taking a slight left back home.
AAA is the best source for route itinerary. If you don't have a membership, PM me and I'll get some info for you.