This may sound strange, but my dog used to fight me constantly (still does from time to time). It gave me alot of insight into what it would be like to seriously fight a dog. The best thing I found to do when a dog clamps on your hand is to shove it in to reach the back of the mouth. Its an unexpected move that gives you some control and, as shakran said, its much harder and painful to attempt pulling your hand out. I also learned that dogs are surprisingly flexible. I remember trying several submissions on my dog during an attack that he would quickly slip out of. Pinning the dog on its stomach and controlling its head is usually the most successful one. If I wasn't worried about keeping the dog in tact, or it posed a very serious threat I'd do the following. After you shove your hand in grip the dog's head as hard as possible. Take your other hand, raise it high, and hammer strike the top of its skull right between the eyes (or somewhere in that vicinity). If its still going, maintain your grip, place your other hand on the top of the neck, and move your weight onto that hand as if you were about to do a cartwheel (you should have some control over the head since the dog is trying to bite your hand). This will push the dog towards the ground, and when that happens pounce onto its back, get your arm around its belly, putting you directly on top of it and use the momentum from your cartwheel start to roll yourself, and the dog, sideways so that you are beneath the dog and your both facing up on the ground. Once you're in this position you can bite the dog's shoulder, strangle it, or break its neck.
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