I've been using AcquisitionX for OSX (now Universal Binary for Intel Macs). I love it...it ususally finds what I'm looking for, and the UI is simple and intuitive. No tracking/opening ports, configuring ul/dl speeds, none of that nonsense. Fire it up and get your music.
I've also used Kazaa Lite with good results. My p2p app of choice for XP. I tried morpheus once and is it a mess.
Bittorent is too complicated for me to configure. I can never get it to work consistently.
If I can't find what I'm looking for on acquisition, then ok I'll use iTunes. I think I've bought 3 songs in the last year.