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If the point of telling them is to discourage drug/alcohol use, dribble it out over the years, because chances are, by the time you think they're just discovering drugs/alcohol, they may have already started experimenting.
If the point of telling them is to just let them know that you had a sister, you could do it either way. My mom told my sister and I all of a sudden before my cousin's wedding that we had an older brother, and she had given him up for adoption when she was 19. Her point in telling us was just so that if a family member were to ever slip and let it out, we wouldn't be surprised.
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Don't trust anything that can bleed for a week and not die. Oh wait, that's me... nevermind... you can trust me. 
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