Spongebob Squarepants - Drink every time someone says another character's name or "Krusty Krab". It's like personal pronouns don't exist on that show.
Quick aside- before you do anything, get the song "Roxanne" by the Police... divide the people in the room into two groups- one group drinks every time he says "Roxanne", the other half drinks on "you don't have to put on the red light". It's a great party-starter, and the ending is the real payoff. Have at least 2 beers in your hands when you start.
And I have a different Family Guy system:
Drink:
* every time Peter laughs
* every time Chris laughs
*every time Lois admonishes or yells at someone. Drink twice if it's Peter.
* at every cutscene- one drink if it's supposed to be a memory, two drinks if it's totally absurd/random
* every time someone hates on/makes fun of Meg
* every time Peter is seen drinking, you drink. If he goes through multiple beers, you drink for each beer he finishes.
* every time Peter is actively drunk on screen, you drink at will.
* every time Brian sips a drink, you drink. If he finishes a drink, you finish your drink.
* any time Brian does something actually dog-like, drink twice
* any time Stewie says something bad and it's passed off/misunderstood as baby talk.
* Any time Quagmire issues one of his catch-phrases or spouts sexual innuendo
* Drink twice if you don't see, but only hear Bonnie deliver a line (because she's not on screen).
* Drink every time Adam West says/does something ridiculous.
* any time Stewie references liking men or does anything effeminate.
* The first time you see any regular/important character other than the Meg, Stewie, Brian, Chris, Lois, or Peter in an episode, you drink. Examples: Joe, Bonnie, Quagmire, Cleveland, Mort Goldman (drink twice if you see his wife), Neil Goldman, Tom and Diane, Adam West, etc.