the reason that infection was all one way towards the native americans was because of conditions in europe at the time.
Due to their highly agrarian? argicultural? society, the stable food source allowed europeans to congregate into large cities and live at a high density. Combine that with unsanitary conditions (dirty drinking water, fecal matter in the streets, etc.) and you had the perfect conditions for disease to ferment and grow.
Europeans were just really dirty compared to the native americans who lived in small communities produced by subsistance hunting supplemented by gathering and a little argiculture in places.
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