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I've never known anyone who had depression problems while on Accutane. And honestly, for some with disfiguring acne, all of the risks associated with Accutane are outweighed by the benefits. But yes, sunscreen is a must for those on it, as is an investment in a large tub of moisturizer.
There are a lot of people on drugs that require they also wear sunscreen. I can also imagine that there the benefits outweigh the risks.
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Well you do now. I mean acne sucked but I didn't hate myself becuase of it. Enter Accutane. Uncontrollable mood swings, first I wanted to punch my parents in the face and then I just wanted to cry. Took me a week of that absolutely horrible and harmful chemical before I said adios.
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This, already, signifies that our sun exposure is taken into consideration in our genetic makeup.
Your primary points regarding the dimers are absolutely correct. That does not, however, mean that our genetic makeup has not greatly improved our sunshine survivability over the course of thousands of years.
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I was with you until you said that evolution has improved our sunshine survivability. It clearly has not. Whiter skin is WORSE for sun protection than black skin. It's blatant -- unless you have skin as black as the darkest African, you have evolved NEGATIVELY with regard to sun exposure. The whiter our skin, the more likely we are to get sunburn and skin cancer.
The only reason we evolved "whiteness" is that blackness was selected against in areas away from the equator because it resulted in rickets. A lack of Vitamin D (and consequentely calcium utilization) causes lots of problems during birth, so the whiter you were, the more likely you were to survive. We suplement our diets now with Vitamin D (not truly a vitamin, btw, since our body produces it) but that certainly does NOT mean that white skin is somehow an evolutionary improvement. It's not -- we're worse off than every ancestor back to the Paleocene.
I'm totally an au natural person at heart, and I'd normally agree that chemicals are "generally" bad for you. But this is one of those times that the penicillin argument comes into play. What's worse? Skin cancer or a little bit of percieved "chemical" influence on your skin (with no science to back it's actual effect on your skin, I might add) ?