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Like willravel and others mentioned, I think 2001 is very prominent in this category. The suggestion that a spiritual transformation is the next massive leap for life (don't want to say mankind - because the apes weren't yet human when they had their intelligence leap) and that it would rescue us from the narrowing divide between human and machine was very profound.
I would also like to add Eternal Sunshine of the Spotless Mind to the list. If you haven't seen it, it's set in modern-day north america and centers around a hypothetical psychiatric procedure that can selectively erase memories. If you've had a bad experience in life, you just go have the memory erased. It brings up the idea that our life is simply the collection of our own memories. The acting's great too.
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