From what i read, the biggest difference between the two is how much memory the processors can support, and the opteron can be used in 1, 2, 4, or 8 processor set ups where the 64 can only be used in single processor setups. If your not going to run over 4 gig of RAM and not going to be running multiple processors (I can't really think of a reason a gaming rig would need more than 4 gig or more than one higher end processor), then go with the 64
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