I voted for the Lexus. Second choice is the FX45 (I'd go for the 35 since it's smaller and sportier, but it's up to you.) The Lexus has decent fuel economy for an engine that size, lots of safety features, Toyota reliability (which is just as good as Honda reliability,) and feels great to drive. It has plenty of extras that make it a pleasure to drive and fun to play with at red lights.
The Audi will be plagued with VW's electrical issues, the Jag is heavy, underpowered, and less refined than the Lexus, and as nice as the Acura is, I can't come up with a rationale for recommending a front-wheel-drive car to someone who lives in California (it's a personal preference, but I live in New England and my car is RWD.)
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