I don't see how anyone could compare a gun's use as common self-defense, which is pretty much always going to be one, two, maybe three center-of-mass shots, to its precision use by assasins and other professionals of the life-ending kind.
I can poke you hard with two fingers pretty much anywhere on your body, and you'll be annoyed- but if i strike the right spot, you die. The common user does not have the time, accuracy, and opportunity to make the kind of shot required to put down an attacker with a .22- professional killers do. That's why the word "professional" is in there.
So, if one can defend their home by sneaking up in perfect silence and giving the intruder a round behind the ear, or in the soft spot on the back of the head, then they're perfectly welcome to use a .22... until then, i'd go with a shotgun, or a handgun with actual stopping power.
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