Alcohol- been drunk several times and I am quite rowdy, I must say. (I also like to speak in French...and only French.)
Nyquil (Overdose)- used to down a couple bottles before class in high school. I was so unhappy.
Asprin/Excedrin (Overdose)- worst I did was in one of my suicidal fits. I took 77, and to this day I do NOT know how I survived. Needless to say, I was sick for days.
Marijuana- Fun!
Diet Pills (with Ephedrin- supposedly a mild form of speed?)- Made me really really really really hyper. I lost weight, I'll tell you that. Then again, I WAS anorexic, so maybe that had something to do with it?
And...I swear, I smoked pot with a guy that had to have laced it with something. The experience was hella trippy.