I think Jack is still reeling from the bit of information that Sawyer dropped on him only a few hours earlier... that Sawyer had met his Dad in a bar and his Dad had appologized...
This is all tied up with Jack's wife and the fact that he couldn't save her. I bet it turns out that his Dad, tried some operation on her and in the end it killed her.
Add to this the fact that Desmond just showed up out of nowhere...
All of these coincidences would drive a rational mind like Jack's to distraction.
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"My hands are on fire. Hands are on fire. Ain't got no more time for all you charlatans and liars."
- Old Man Luedecke
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