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Originally Posted by heccubusiv
Well since Vicodin plan vicodin is 5/500, with the 5mg being the Hydrocodone, and the 500 being Acetaminophen. Pharmacology proves that you should only take 2 grams of Acetaminophen a day(through insurance company) but liver toxicity does not take place until 3g/day. With all toxic levels, that is a LD50, a lethal dose to effect 50% of the population. I have not been able to find a lethal dose of Hydrocodone
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The actual max for acetaminophin recommended is 4 g daily. Toxicity doesn't begin usually until 6 g. I think you cut your numbers in half there.
Hydrocodone is difficult to determine an exact leathal dose, because as already defined it varies widely amongst individuals. What essentially happens is you take to large of a dose and it slows your breathing to much, and you die. That's generally the cause of death from opiate overdose in these meds.
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Originally Posted by skinnymofo
for vic's its all about the aspirin in them. an unhealthy amount for your liver is 4000mg (a one time thing seperated will be ok) but if you do it for days at a time is pretty damn bad. start taking more and your eyes could bleed do to it.
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There's no aspirin in vicodin. I think you're confusing it with acetaminophin, which is tylenol.
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Originally Posted by raveneye
I don't know what the LD50 is for vicodin, but I know that it doesn't take much to make you go deaf. And there's not cure for the hearing loss except a cochlear implant.
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Hearing loss is pretty rare, and is generally only associated with abusing the drug and overdosing.
To better answer the origional question, the "average" joe who is opiate naive it's going to usually take a lower dose to be lethal as opposed to someone who has taken it before. You could hypothetically take a 250 lb dude who's never had opiates before and kill him with a dose that a 90 lb lady needs simply to relieve pain if she's a chronic user for some pain condition or other. This is just with the opiates.
What tends to "get" you is the acetaminophin toxicity on your liver. If you consistantly take toxic doses of that (especially combined with alcohol) you're going to destroy your liver, and you can end up dying a rather long uncomfortable death, not the falling asleep and stopping breathing peaefully than an opiate OD would do.