Quote:
Abstract:
Consanguineous marriage is strongly favored in many large human populations. In the most parts of south Asia, consanguineous marriage account for 20% to over 50% of the general population .
The effect of consanguinity on hereditary deafness has been well studied and documented. Many authors have suggested that approximately one half of sensory neural hearing loss in children can be attributed to hereditary causes.
This research was carried out in Rehabilitation Deputy of welfare organization of Iran in seven provinces. 1352 infants and preschool aged children participate in this research. The prevalence of SNHL due to consanguineous marriage in first cousin and second cousin were studied.
Consanguinity was found among 45.7 percent in first cousin and 17.2 percent in second cousin. Hereditary Factors were thought to be the cause of 863 (62.9 percent) of bilateral SNHL children in this research.
The incidence of hereditary hearing impairment is very high in developing countries compared to developed countries . Prevention is essential to reduce the incidence of genetic hearing loss. Consanguinity should be discouraged and genetic counseling is to be applied at least for those at risk of developing genetic diseases including hearing impairments.
|
http://www.uswr.ac.ir/IRJ/Lpublished/HearingImp.htm
Quote:
|
Objective: Consanguineous marriage is a widely practised social custom in Asia and northern Africa. In south India, Dravidian Hindus have contracted consanguineous marriages for over 2,000 years. In the present study, the influence of consanguinity on the prevalence of visual disorders was examined in patients attending a specialist genetic eye clinic. Subjects and Methods: A total of 2,335 patients attending Sankara Nethralaya, Chennai, India, were screened for genetic eye disorders over a five-year period. The patients were drawn from all parts of India and from neighbouring countries in south Asia. Results and Discussion: Six hundred and seventy-three (28.8%) of the patients tested for ophthalmic genetic disorders reported a family history of consanguinity. The majority (n = 574) of these families were from south India. In the patient group as a whole, the most common form of consanguineous union was between first cousins (n = 367), followed by uncle/niece marriage (n = 177), equivalent to a mean coefficient of inbreeding alpha = 0.0202. Among the consanguineous families, 430 of 673 (63.9%) had retinitis pigmentosa, 167 of these cases were autosomal recessive and 199 were isolated cases. The public in regions such as south India should be made aware of the merits and demerits of consanguineous marriages.
|
http://content.karger.com/ProdukteDB...name=66334.pdf
Quote:
|
Offspring of consanguineous matings (including incest) have, on average, about two-and-a-half times the rate of congenital malformations or genetic disorders as is found among non-consanguineous marriages in the same ethnic group.
|
Quote:
Case 1
A 10-year-old female child, born full term of a first degree consanguineous marriage presented with painless stiffness and contractures at large joints involving the knee, ankle and elbow since the age of 6 months. The flexion deformity of joints had progressed rapidly making the child almost crippled and bedridden by the age of 5 years. Multiple translucent, asymptomatic, flat papules, 2-5 mm in size present on the nape of the neck and alae nasi, had appeared since 2 years of age. She also developed asymptomatic, progressively enlarging subcutaneous nodules and tumor masses [Figure - 1] varying in size from 2 x 2 cm2 to 10 x 10 cm2 on the scalp, face, back and extensor aspect of the limbs. Nodules were prominent on the pinna causing its deformity.
|
Quote:
The relative risks and odds ratios show that consanguinity
significantly elevates prereproductive mortality.
However, consanguinity has always been relatively rare in
the Utah population. Thus, it accounts for only a small
proportion of early deaths, as revealed by the population
attributable risk estimates. This analysis underscores the
importance of considering the total public health burden
of consanguinity in human populations.
|
Christ, I NEVER thought I'd have to be defending the concept that brothers should not have children with their sisters. I had a VERY hard time finding anything where it was a analysis of brother-sister unions, and do you want to know why? Because since before written history began we knew this caused a LOT of problems. Most of the problems only look at first and second cousins at that seems to be the minium 'safe' difference where there is only a smallish increased chance of recessive defects. Only one of the above quotes was looking at a first degree consanguineous mating, the rest all apply to cousins.
You know, its nice to be all accepting of every deviation in human sexuality, but in this case its time to shake your heads and say 'thats not right'.
Jail time, etcetera, I don’t really have much of an opinion on, but the act of having children with your sibling is wrong, yes a moral judgement, wrong.