A note on MS Access: Yeah, the JET engine craps out at 65k records, etc. etc., but the shiny things (forms and other front-end bits) are a snap to throw together, and the standardization of the user interface coupled with it being wrapped up in MS Office makes it an excellent choice.
I use access to build front-ends for big backend databases in mySQL. Anytime the boss wants a new sparkly toy, it's nothing to whip up a new form or report in access built on a mySQL query.
It's almost the best of both worlds, easy Lego frontend, powerful backend. Just that messy connection stuff in the middle.
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