| Definitely any protect quest in any game ever, with the possible exception of Ico.  Prince of Persia: The Sands of Time suffered from the flaw, and it led to no end of frustration.  Although the fact that I never mastered the combat in that game may have something to do with this.
 In terms of RPGs, random battles every three steps is the most frustrating thing I have ever experienced in a video game.
 
 In God of War: Spoiler: The last three bosses really put a damper on the game as a whole, I thought.  Between Ares' unblockable, super-quick, out-of-nowhere, massive-damage attack that was used every three seconds and another bloody protect quest against a thousand versions of yourself, I had to turn the difficulty down to finally finish the damn thing.  And that is a pain on the ego, I'll tell you that.
 
 Also, there was a bunch of stuff in Spider-man 2 that was broken and needlessly infuriating.  Any battle with Mysterio, for example.
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