"Find something you love to do, and you'll never have to work again"
Do what you love. If you want to be a scientist, then become a scientist. If you want to be educated in a 'major' university, then apply.
You aren't the first person who has wanted to switch majors, and registrars at universities have heard the story a lot. I don't think it matters that you've done your prep work in PoliSci, the university is there to teach you, and all you need to prove is a willingness to learn. If they don't accept you into the Science program of your choice, get enrolled at the University as a PoliSci major, THEN switch your major.
Apply, you just may shock yourself.
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As soon as you stop living, you start dying....
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