First, you may be able to get into a real university science program, even with the poli-sci background. The basic requirements to start are pretty low.
Secondly, 2-3 years is not long. I was in school until I was 32 and I took a few paths which I backtracked from to get to where I wanted to be. I did everything from environmental work, to genetics labs, to engineering.
The only advice I would give you beyond that is FOCUS. Figure out what in science you want to do early and work twords that goal. Thats one thing I didn't do, and yes it cost me time. More importantly though, if you focus you know what you NEED to do early on. For me once I figured out my path I knew I needed very high marks. I went in from day one knowing I needed close to all A's and as such I had an advantage over students who were just figuring out what they wanted to do and taking it easy. After I was accepted into a post grad program, a few even came to me, half joking, asking me to start to screw up in hopes they could raise their class rank since it no longer mattered to me. I've been in both groups at times and it’s a lot more fun being in the top group than not quite having it.
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