Definitely pack all the cards, hard drive, and heat sink separately. Make sure everythuing is very securely screwed down, and that no tabs, screws, etc. on the case can easily hit the motherboard. Luggage is subjected to an incredible amount of abuse.
I transported my computer in my luggage on a flight once. I put the case in a large suitcase and packed it with 6-8 inches of clothes on all sides. When it arrived, the frame of the case was bent (and it was an old, heavy-duty Enlight tower that weighed 40 pounds!), and I had to re-seat all my cards and memory before it would boot up.
A friend took his computer on a trip, too. In addition to the cards and memory being unseated, the inside of the case deflected by about a half inch, and shoved a screw into the back of his motherboard. I had to re-solder a few traces, but it survived, thankfully.
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