Late to the discussion - but I just joined up.
If RAB is Regulus, and the horcrux is a locket, then it's probably the one mentioned in OotP. While cleaning out the cabinet in the drawing room, they come across "a heavy locket that none of them could open." Keep in mind, Mundungus has been nicking items from the house since Sirius died.
It took two (Harry and DD) to retrieve the fake horcrux. It probably took two to retrieve the first one. If so, one of them would probably need to be knowledgeable in potions in order to provide an antidote (if one exists) and to replace the potion. Several possibilities come to mind: Snape, Slughorn, and Lily Evans (Potter), based on their supposed knowledge of potions. Admittedly, none of them really fit.
JKR has left tons of clues (some probably red herrings) that could lead Snape to be either evil or acting under orders. He still needs to have a major confrontation with his internal demons (hatred of Harry via James & Sirius), which will probably lead to him either accepting or rejecting some final redemption.
She's also yanking chains with DD's "Burning Day" funeral a la Fawkes. Any further interactions with him will probably be through his portrait.
Sirius's relatives: Regulus (younger brother: dead), the Black sisters (his cousins: Bellatrix Lestrange, Andromeda Tonks, Narcissa Malfoy), and the sisters' children: Nymphadora Tonks and Draco Malfoy. Not sure why Harry can control Kreacher when there are others who are blood relatives.
The book came across as if JKR had read a LOT of fanfiction. She even uses DADA for Defence Against the Dark Arts. In an interview (or maybe her official website) she had already said that Blaise was a boy. HBP was the first canon mention of it, and the first time ever that his race was mentioned.
Hermione's age (oldest of the three, not youngest) finally gets mentioned in canon. JKR has a bit of a problem with birth years.
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