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Originally Posted by THGL
I've had great success with Roundup, but not the spray-bottle kind you can get everywhere. Buy it un-diluted at a home center and pick up a cheap garden sprayer then mix it yourself (I always add just a tad more solution to the water than what's recommended).
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I do the same, however I also add about a teaspoon of dish soap, you know the liquid, it helps it stick to the leaves, so it does not drip off as quick.
Also based on the rock patio, this might not work, but they do have a granular pre-emergent, once you kill the weeks, you can sprikle some of that, and keep the weeds at bay for a couple of months