I think the damaging effects come when you cannot function as a "normal" person because your standards of yourself prevent that. I think that most people make fun of their self because they are comfortable with who they are. They don't really hate themselves, they just joke around. I do the same thing, I joke around about myself but I never accept those are truths.
I guess whether you accept the self-depreciating as truth to the point where it "damages" you psychologically, mentally or sometimes physically is where the line should be drawn.
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