Stay with one kind of alcohol. Don't switch back and forth between beer, liquor, and everything else, I think the medical reason has to do with the ratio of absorbtion rate to metabolizaiton rate, but I can't remember and I don't feel like looking it up. I do, however, know that I can sober up after a Poland Spring bottle full of Everclear faster than I can sober up after several beers (and Smirnoff ice, etc.) mixed with a few shots.
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