The answer is pretty much whatever lets you sleep at night.
For me, I'm content knowing that there is no meaning to existence. While some would question why I would bother to live, I'd just as well say, why not? If there is no meaning, then there can be no contrameaning. Thus, contrary to what most people would understand, lack of a meaningful existence doesn't justify a reason to end it. I think it's silly to end things for no good reason.
I think that our need need for a meaningful existence stems from how our brians are structured. We think in terms of labels. When something is incapable of receiving a label, not just becuase it can't be understood, but because it truly isn't capable of being labeled, our brains short circuit.
I'm very tired right now and at a loss for how I want to finish this train of thought. But before I go I'll say that Douglass Adams, the author of the Hichhiker's Guide to the Galaxy, does a wonderful job at poking fun at the insignificance of life and the search for it's meaning. The subject itself is rather unapproachable since it deals with, well, things that can't be dealt with. If you can't label something you very well can't say much about it. However, Adams is able to indirectly shed light on such things through humor and parody. I'd recommend finding some of his interviews on the net where he talks about his stance on Aetheism- he's probably my favorite Aethiest in the entire world.