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An easy solution would be to write a simple Perl script or something that takes a list of e-mail addresses and a message file and then simply runs "mail -s `Subject` `address #x` < message" or something like that, with appropriate timing between each iteration so you don't overload your mail server.
All you'd need to do it is grab a Linux/BSD machine or else a Windows machine with Cygwin and set up mail [or whatever mail program you do want to use] to point at the appropriate SMTP account you're sending from.
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