In my opinion, depression should not be an aspired profound place of being. It is about emotion conflicting with cognitive processes. Anything looked at as profound (in art, poetry or literature) is an expression of thought or feelings and it provokes insight and questioning. It conveys a profound message to the viewer, enabeling them to understand a perspective.
Depression is a disease, it varies in depth and scope for different people, and should be addressed. Depression is saying that something is wrong. Taking meds only fixes the symptoms, it does not address the core reason for the conflict. I doubt that anyone considered profound for their expressions feel special or good about it - it's a dark, nasty, horrible place to be.
*Note: Medication is good for those that suffer depression for biological/neurological reasons, please don't jump on me for that!