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Here's an example of isolation that works for functional strength.
To get any kind of workout for my calfs, I have a couple of choices:
Load on a ton of weight, and do step ups or calf raises.
Use some machine or another to isolate the weight to my legs, seated calf raises perhaps.
Now, if I were to do standing calf raises, I would be limited by the amount of weight I can hold on my sholders, or arms. In my case, that's pathetically low.
With a seated calf raise, I'm not limited by my arms and shoulders. Sure, you could say that I should really try to even out, but a much bulkier upper body will not help me run a 10k faster.
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