Well, prior knowledge of the game is a large part of it, I must admit. I played beta so knew right off which quests to grab and which not to. The best places to level are usually caves of low ac, low damage creatures that respawn fast enough to be back by the time you've made a circle. Most of the ones I used in beta and early release have been changed but there are still decent spots out there.
Generally grinding results in 30-40k/hour depending on level and class. For 45 the traditional spots are ogres in tanaris and yetis in feralas, not sure if any of them have been changed recently. The best I've ever done questing is somewhere around 32k/hour for 2 hours but again, quests require a ton of prior knowledge to make them real efficient (though some might find questing more fun).
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