Many epistemological arguments involve certainty in justification, and a prevailing view is that knowledge requires certainty to be absolute. Any doubt (or chance of doubt) necessarily prohibits knowledge.
My own view regarding knowledge gravitates toward what is referred to as the 'fallibilist' approach: it is impossible for us to achieve absolute certainty, and therefore any such high-standards approach to knowledge results in skepticism. What we as humans 'know' does not rely on absolute certainty, but rather on good enough reasons for believing a (necessarily true) proposition. G.E. Moore's response to skepticism also appeals to me: it is more reasonable to believe we at least know some things than to believe we know nothing.
That being said, there is a low ceiling on what we can 'know' and comprehend. Humans and their faculties are decidedly finite.
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