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Originally Posted by skier
Another is when death is certain (in the close future, eg. terminal cancer) and your quality of life is reduced to the point where you can no longer enjoy it, in addition to the anticipated pain and suffering before your end.
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My brother was schizophrenic, and although fairly healthy in any other sense, his quality of life was definitely diminished. He was functional; he had a job, medical care when he accepted it, and a place to live (with us). He had a lot of friends and a lust for playing the guitar. He still chose to end his life; I can't fully understand why but I will never bear him ill will for it. I suppose that's what makes the world go 'round, different perspectives.