I had to do that a few years ago for several hundred pictures. The pictures liked to squirm around, especially those with any warping. Ended up making a couple picture holders from white construction paper. One had a 3x5 hole, another for 5x8. Secured them to the scanner bed with tape. Place a picture in the hole, slide a book over it, hit the scan button. It went much faster than holding things while lowering the scanner top.
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